Vascular effects of loop diuretics

Vascular effects of loop diuretics.

Although it is generally believed that the beneficial effect of loop diuretics is the result of a rapid increase in diuresis, substantial evidence, from a large number of in vitro and in vivo experiments, has accumulated showing that administration of furosemide causes direct vascular effects, which probably contribute to its acute clinical effects. Several mechanisms are involved in the vascul...

Vascular effects of diuretics in heart failure.

Loop Diuretics in Clinical Practice

Diuretics are commonly used to control edema across various clinical fields. Diuretics inhibit sodium reabsorption in specific renal tubules, resulting in increased urinary sodium and water excretion. Loop diuretics are the most potent diuretics. In this article, we review five important aspects of loop diuretics, in particular furosemide, which must be considered when prescribing this medicine...

How do loop diuretics act?

In the thick ascending limb of the loop of Henle, NaCl reabsorption is mediated by a Na+/2Cl-/K+ cotransport system, present in the luminal membrane of this nephron segment. Loop diuretics such as furosemide (frusemide), piretanide, bumetanide and torasemide bind reversibly to this carrier protein, thus reducing or abolishing NaCl reabsorption. This leads to a decrease in interstitial hypertoni...

Synergistic action of metolazone with "loop" diuretics.

Features of the brachydactyly in this family were similar to those described by Vidal,4 and the variation in severity among family members has been reported.5 The association of the condition with colorectal cancer may have been due to chance or may be a true syndrome, permitting identification of patients at risk for colorectal neoplasia. We should be interested to hear from others who may hav...